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Completed

NCT Number: NCT05268159

Disconnection and Unilateral Spatial Neglect

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (<6 months). MRI scans have also been done in routine care.

The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hop Swynghedauw

Lille, 59000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First hemispheric adult stroke patient
  • Non-opposed to inclusion
  • Confirmed by MRI
  • Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

Exclusion criteria

  • History of previous stroke or neurological disorders
  • Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder
  • Uncorrected severe loss of visual acuity
  • Contra-indications to MRI

Treatment and study plan

Cognitive Assessment

Other

Assessment of unilateral spatial neglect, attention, executive functions and memory

Primary outcomes

  1. Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Secondary outcomes

  1. Assessment of personal Unilateral Spatial Neglect with the Fluff Test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  2. Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  3. Assessment of Attention with the Test of Attentional Performance

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  4. Assessment of Executive Functions with the Stroop Test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  5. Assessment of Executive Functions with the Trail Making Test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  6. Assessment of Executive Function with Verbal and Categorial Fluency test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  7. Assessment of Executive Functions with the test of commissions

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  8. Assessment of verbal Memory with the verbal span task

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  9. Assessment of verbal Memory with the Grober and Buschke Task

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  10. Assessment of visual Memory with the Doors test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  11. Assessment of visual Memory with the Rey figure test

    Time frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

  12. Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion)

    Time frame: up to 6 months

  13. Postural assessment with the PASS

    Time frame: 1 month after stroke

  14. Postural assessment with the PASS

    Time frame: 3 months after stroke

  15. Gait assessment (Lindmark score)

    Time frame: 1 month after stroke

  16. Gait assessment (Lindmark score)

    Time frame: 3 months after stroke

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Neural Basis of Unilateral Spatial Neglect After Stroke: a Retrospective Disconnectome Based Study

Acronym: DISCONEGLECT

Important dates

Study start
2011
Primary completion
2021
Study completion
2021
First posted
Mar 7, 2022
Registry last updated
May 18, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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