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OpenTrials
Completed

NCT Number: NCT06888882

Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients With Hypertensive Angiopathy or Cerebral Amyloid Angiopathy

Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia.

To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.

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Key information

Conditions

Hypertensive Arteriopathy Amyloidosis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebral Amyloid Angiopathy Cerebral Arterial Diseases Cerebrovascular Disorders Intracranial Arterial Diseases Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nîmes

Nîmes, Occitanie, 3029, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient registered in the CHU de Nîmes (France) stroke database with lobar intracerebral hemorrhage [ICH], subarachnoid hemorrhage or cortical superficial siderosis for CAA or basal ganglion ICH for HA
  • Patient managed at the CHU de Nîmes (France) between 01/1/2015 and 31/12/2024
  • Patient with T2-weighted MRI performed with a 3T magnet

Exclusion criteria

  • Refusal to participate

Treatment and study plan

Primary outcomes

  1. Sex

    Time frame: baseline

    Comparaison of both populations (HA/CAA), H/F

  2. Hypertension

    Time frame: baseline

    history of hypertension (Yes/No)

  3. Age

    Time frame: baseline

    Age at time of T2-weighted imaging,

  4. Time

    Time frame: baseline

    Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,

  5. MRI view

    Time frame: baseline

    T2 performed using coronal or axial imaging (axial / coronal

  6. hypercholesterolemia

    Time frame: baseline

    history of hypercholesterolemia (Yes/No)

  7. Hemorrhagic lesion

    Time frame: baseline

    Hemorrhagic lesion load on T2*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)

  8. Subcortical lobar DPVS

    Time frame: baseline

    Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for >40 DPVS).

  9. DPVS of basal ganglia

    Time frame: baseline

    Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for >40 DPVS).

  10. Diabete

    Time frame: baseline

    history of diabetes (Yes/No)

  11. Smoking

    Time frame: Baseline

    current smoking (Yes / No)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Acronym: HA-DN-DPVS

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 21, 2025
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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