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Completed

NCT Number: NCT04966039

Diffusion Weighted Magnetic Resonance Imaging of Brain in Monochorionic Twin Pregnancies With Demise of One Fetus

Diffusion weighted imaging (DWI) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (DTI) can quantitatively evaluate the fine structure of white matter in brain. In this study, conventional and diffusion-weighted MRI (DWI, DTI) sequences were used to analyze the brain of monochorionic twin pregnancies with demise of one fetus.

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Key information

Conditions

Twin Pregnancy With Antenatal Problem

Study type

Observational

Primary location

Peking University Third Hospital

Beijing, China

About this study

With the incidence rate of twin pregnancy increasing, the incidence of intrauterine death of twin pregnancies is also rising, which has great impact on the morbidity and mortality of the other fetus, and increases the mortality of fetal survival, premature birth, brain damage and long-term sequela. Therefore, it is necessary to examine the central nervous system of the surviving fetus of twin pregnancy and intrauterine death. When the surviving fetus is complicated with nervous system abnormalities, conventional MRI can generally make a diagnosis. However, some of the surviving fetuses may not find other structural or echo abnormalities on B-mode ultrasonography, and even these fetuses do not find structural or signal abnormalities on routine MRI examination. Whether the surviving fetuses may have brain abnormalities cannot be detected early by the above methods. Diffusion weighted imaging (DWI) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (DTI) can quantitatively evaluate the fine structure of white matter in brain.

The present study is to use conventional sequence and diffusion-weighted imaging (DWI, DTI) to analyze the brain of monochorionic twin pregnancies with demise of one fetus, which aims to find the potential brain abnormalities early and provide some guidance for the clinical diagnosis and treatment in the next step.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Twin pregnancy was diagnosed and one fetus died in utero
  • Twin pregnancy with one abnormal fetus
  • Singleton pregnancy with abnormalities outside the fetal brain

Exclusion criteria

  • Those who can't cooperate with MRI examination, such as those who have metal, claustrophobia or can't insist on scanning.
  • Pregnant women with gestational age less than 20 weeks.

Treatment and study plan

No intervention.

Other

There was no intervention.

Primary outcomes

  1. basic information

    Time frame: baseline

    age

  2. basic information

    Time frame: baseline

    gestational age

  3. basic information

    Time frame: baseline

    uterine height

  4. basic information

    Time frame: baseline

    abdominal circumference

  5. basic information

    Time frame: baseline

    intrauterine death time of one fetus

  6. MRI

    Time frame: baseline

    DWI sequence (ADC value)

  7. MRI

    Time frame: baseline

    DTI sequence (FA value)

  8. MRI

    Time frame: baseline

    conventional sequence

Sponsors and collaborators

Lead sponsor

Peking University Third Hospital

Other

Registry information

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Jul 19, 2021
Registry last updated
Jul 19, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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