NCT Number: NCT06892041
Diffusion MRI for Quantitative Assessment of Myofascial Pain
The purpose of this study is to assess the diagnostic accuracy of diffusion MRI for evaluation of the jaw muscles for patients with masticatory myofascial pain syndrome.
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Conditions
Age range
18 year–65 year
Sex eligibility
All sexes
Study type
Observational
Primary location
New York University, New York, United States
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Men and women 18-65 years of age
- Ability to give informed consent
- Symptoms meeting criteria for normal or latent/active temporomandibular myofascial pain
Exclusion criteria
- Contraindications to MRI scanning including severe obesity or difficulty in laying in a supine position, intracranial clips, metal implants, external metallic devices/objects/clips within 10mm of the head, suspected or confirmed metal in the eyes (history of welding or similar activity), claustrophobia, cardiac pacemaker or pacing wires
- Pregnancy or breast feeding
- Traumatic injury of masticatory muscles or temporomandibular joint within last 12 months
- Mandibular fracture within last 12 months
- Initiation of additional treatment of myofascial pain within the past 1 month
- Received masseter Botox within the last 4 months
Treatment and study plan
Primary outcomes
-
Difference in mean diffusion MRI parameters of temporalis and masseter muscles between patients at the normal stage and those at the latent/active pain stage.
Time frame: Day 1
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Weill Medical College of Cornell University
Other
Collaborators
- National Center for Complementary and Integrative Health (NCCIH)
- New York University
Registry information
Official study title
Development of RPBM for Quantitative Assessment of Myofascial Pain
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Mar 24, 2025
- Registry last updated
- Oct 1, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.