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Completed

NCT Number: NCT04359251

Different PEEP Settings of COVID-19 Induced ARDS

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

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Key information

Conditions

COVID-19 Acute Respiratory Distress Syndrome Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Mechanical Ventilation Pressure High Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhongda Hospital, Southeast University

Nanjing, Jiangsu, 210009, China

About this study

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COVID-19 patients with mechanical ventilation
  • PO2/FIO2<300mmHg
  • ages>18 years

Exclusion criteria

  • pneumothorax
  • pregnant
  • hemodynamics is unstable

Treatment and study plan

Gas exchanges at different PEEP

Other

Gas exchanges measurement at different PEEP

lung mechanics at different PEEP

Other

lung mechanics measurement at different PEEP

Hemodynamics changes at different PEEP

Other

Hemodynamics changes measurement at different PEEP

Primary outcomes

  1. Respiratory system compliance improvement

    Time frame: 20 minutes

    the respiratory system compliance was compared among three groups

Secondary outcomes

  1. Gas echanges improvement

    Time frame: 20 minutes

    P/Fwere compared among three groups

Other outcomes

  1. hemodynamics improvement

    Time frame: 20 minutes

    MAP were compared among three groups

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Apr 24, 2020
Registry last updated
Apr 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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