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OpenTrials
Completed

NCT Number: NCT03824301

Different Modes of Ventilation During Cardiopulmonary Bypass

66 patients divided into 3 groups with different modes of ventilation.

Completed

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Key information

Conditions

Postoperative Pulmonary Dysfunction Lung Diseases Pleural Diseases Pleural Effusion Pulmonary Atelectasis Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ain Shams University cardiothoracic hospital

Cairo, Egypt

About this study

Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoingvalve surgeries
  • Patients undergoing coronary artery bypass grafting surgeries

Exclusion criteria

  • Emergency cases.
  • Off-pump surgeries.
  • Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value.
  • Massive blood transfusion during surgery.
  • Complicated surgeries.
  • Redo surgeries.
  • Patients with decompensated heart failure prior to surgery.
  • Patients refusal

Treatment and study plan

volume controlled ventilation

Device

Changing modes of ventilation during cardiopulmonary bypass

Pressure controlled ventilation

Device

Applying pressure controlled ventilation during cardiopulmonary bypass Period

Primary outcomes

  1. chest x-ray

    Time frame: after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.

    Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia

  2. lung ultrasonography

    Time frame: after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.

    Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Comparative Study Between Different Modes of Ventilation During Cardiopulmonary Bypass and Its Effect on Postoperative Pulmonary Dysfunction

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jan 31, 2019
Registry last updated
Jan 31, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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