Skip to main content
OpenTrials
Completed

NCT Number: NCT02151305

Different Hemostasis According to the Anesthetic Agents

We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cataract Conjunctival Diseases Corneal Diseases Eye Diseases Eye Hemorrhage Hemorrhage Keratitis Lens Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pterygium Retina Detachment Retinal Detachment Retinal Diseases Vitreous Hemorrhage

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patient scheduled for ophthalmic surgery under general anesthesia
  • American Society of Anesthesiologist physical status I or II

Exclusion criteria

  • hematologic disorder
  • severe anemia
  • liver disease
  • kidney disease
  • taking a medication interfering with hemostasis

Treatment and study plan

propofol, remifentanil

Drug

Sevoflurane

Drug

Primary outcomes

  1. Clotting time of ROTEM

    Time frame: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia

  2. Clot firmness time of ROTEM

    Time frame: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia

  3. Alpha angle of ROTEM

    Time frame: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia

  4. Maximum clot firmness of ROTEM

    Time frame: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia

Secondary outcomes

  1. Hemoglobin

    Time frame: 10 minutes before the induction of anesthesia

  2. Hematocrit

    Time frame: 10 minutes before the induction of anesthesia

  3. Platelet count

    Time frame: 10 minutes before the induction of anesthesia

  4. International normalized ratio of prothrombin time

    Time frame: 10 minutes before the induction of anesthesia

  5. Activated partial thromboplastin time

    Time frame: 10 minutes before the induction of anesthesia

  6. Fibrinogen

    Time frame: 10 minutes before the induction of anesthesia

Sponsors and collaborators

Lead sponsor

Seoul National University Bundang Hospital

Other

Registry information

Official study title

The Influence of Propofol and Sevoflurane on Hemostasis During Ophthalmic Surgery: Rotational Thromboelastographic Study.

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
May 30, 2014
Registry last updated
May 30, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.