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Completed

NCT Number: NCT02303379

Different Endurance Training Protocols in Cardiac Patients

It is the aim of our study to compare the effects of 6 and/or 2 years of either HIT (carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University

Salzburg, 5020, Austria

About this study

The three exercise arms (isocaloric) are composed as follows:

Endurance training: 31 min at 65-75% HRmax, making it a total of 25min; HIT: 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25 min; Pyramid: One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.

All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRmax.

Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate tresholds at 2 and 4mmol/l.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • acute coronary syndrome (STEMI - NONSTEMI)
  • aortocoronary bypass surgery
  • percutaneous coronary intervention (PCI)
  • state after stable coronary heart disease
  • state after heart surgeries
  • state after myo-, endo-, or pericarditis
  • state after heart- or lung-transplantation
  • state after heart failure
  • state after pulmonary hypertension
  • state after peripheral venous disease
  • state after electrophysiological surgery
  • state after implantation of an implantable cardioverter or difibrillator
  • Patients at high risk
  • Patients with cardiac dysrhythmias or sudden death

Exclusion criteria

  • unstable angina pectoris
  • Heart failure (NYHA IV)
  • acute myo-, endo-, or pericarditis or other infections
  • pulmonary-arterial embolism or phlebothrombosis within 6 months
  • hemodynamic instable dysrhythmias
  • hypertrophic cardiomyopathy
  • medical conditions which prevent patients from complying with the exercise program

Treatment and study plan

Continuous Endurance Training

Other

Endurance training with constant work load 31min at 65-75% Hrmax

Pyramid Training

Other

One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.

High-intensity interval training

Other

HIT: 4x4 min intervals at85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min.

Primary outcomes

  1. Physical work capacity (PWC)

    Time frame: 6 weeks or 36 weeks

    PWC will be measured by graded exercise testing on cycle ergometer.

Secondary outcomes

  1. Heart rate

    Time frame: 6 weeks or 36 weeks

    Heart rate will be measured by graded exercise testing on cycle ergometer.

  2. Blood pressure

    Time frame: 6 weeks or 36 weeks

    Blood pressure will be measured by graded exercise testing on cycle ergometer.

  3. Lactate Thresholds

    Time frame: 6 weeks or 36 weeks

    Lactate thresholds will be measured by graded exercise testing on cycle ergometer.

  4. Metabolical and cellular blood parameter

    Time frame: 6 weeks or 36 weeks

    Blood will be taken before and after intervention

  5. BMI

    Time frame: 6 weeks or 36 weeks

    BMI will be taken before and after intervention

  6. Gene expression

    Time frame: 6 weeks or 36 weeks

    Gene expression will be taken before and after intervention

  7. Quality of Life

    Time frame: 6 weeks or 36 weeks

    Quality of Life will be taken before and after intervention

Sponsors and collaborators

Lead sponsor

Paracelsus Medical University

Other

Registry information

Official study title

Effects of Different Endurance Training Protocols on Physical Performance in Cardiac Patients

Important dates

Study start
2014
Primary completion
2018
Study completion
2020
First posted
Nov 27, 2014
Registry last updated
Jan 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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