Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07702188

Different Endoscopic Approaches for Sphenoid Sinus

* Identification of the most effective approach for different lesion types * Correlation between approach and complication rates

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The sphenoid sinus is one of the most anatomically complex and surgically challenging paranasal sinuses due to its deep location ,wide anatomical variation and proximity to critical neurovascular structures.

Important structures are adjacent to the sphenoid sinus include the dura, pituitary, optic nerve, cavernous sinus, pterygoid canal and nerve, internal carotid artery, and cranial nerves III, IV, VI, V1, V2, which are vulnerable to injury with sphenoid disease.

Wide anatomical variation such as Degree of Pneumatization , Septation Patterns , Sinus Size and Shape, Ostium Location ,Onodi Cells, Prominence or dehiscence of nearby structures.

Therefore, surgeons must carefully select the extent of dissection to create a sphenoid opening that matches the patient's pathology while avoiding the risks associated with overly extensive openings and drilling, which may prolong healing and increase the likelihood of scarring and stenosis.

Diagnostic nasal endoscopy procedures and imaging techniques are of great value for an early and precise diagnosis.

Moreover, endoscopic sinus surgery is a safe and effective technique that allows a direct route to the sphenoid sinus.

Because of its close vicinity to important and vulnerable structures of the skull base, delay in diagnosis and treatment can be potentially lethal.

Sphenoid sinus lesions may range from mild, isolated inflammation to erosive tumors with cranial nerve deficits or cases requiring access to a pneumatized lateral recess .

Additionally, conditions such as tumors, encephaloceles, mucoceles, and skull base lesions demand extra preoperative planning and careful technique selection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with sinonasal lesions involving sphenid sinus with or without skull base extension.

Exclusion criteria

  • Severe comorbidities contraindicating surgery
  • malignant tumer extend beyond sphenoid sinus requiring open management

Treatment and study plan

Endoscopic sinus surgery

Procedure

Different approaches include:

type I, sphenoid ostial dilation. type IIa, transnasal sphenoidotomy (sphenoidotomy without ethmoidectomy). type IIb, transethmoidal sphenoidotomy (sphenoidotomy with ethmoidectomy). type III, bilateral, common cavity sphenoidotomy, or "sphenoid drill-out;" type IV, transpterygoid approach, to expose the lateral sphenoid sinus recess. type V, sphenoid nasalization, completely removing the sphenoid sinus floor.

Primary outcomes

  1. To evaluate different endoscopic surgical approaches to the sphenoid sinus

    Time frame: 6 months

    • Complete lesion removal measured by post operative imaging ct
    • Complications examples Csf leakage Optic nerve injury (measured by visual acuity)
    • Carotid artery injury(bleeding)
    • Infection(meningitis csf examination if suspected)
  2. To evaluate different endoscopic surgical approaches to the sphenoid sinus regarding: * Completence of lesion removal. * Complications. - Csf leakage - Optic nerve injury

    Time frame: 6 month

    complications rate (csf leakage , optic nerve injury, carotid artery injury)

    • Recurrence
    • Endoscopic patency of sphenoid osteum and synechia formation

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed elrahman mohamed azzam, lecturer

CONTACT

[email protected]

01099978990

Doaa Araby Mohamed, assistant lecturer

CONTACT

[email protected]

+201119015094

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Different Approaches for Sphenoid Sinus

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.