Different Doses of Colchicine on hsCRP

Inclusion criteria

• Volunteer to participate, understand and sign an informed consent form;
• Age ≥ 18 years old, regardless of gender;
• Patient diagnosed with coronary heart disease requiring percutaneous coronary intervention;
• Complete all planned percutaneous coronary intervention during hospitalization;
• Patient must be treated according to national guidelines for standard treatment of coronary heart disease.

Exclusion criteria

• Known allergies to colchicine;
• Colchicine was taken within 10 days before randomization;
• Abnormal liver function test (alanine aminotransferase >3 times the upper limit of normal value);
• Abnormal renal function test (eGFR<30mL/min);
• Thrombocytopenia (platelet count <100 g/L);
• Uncontrolled infectious diseases;
• Known immune diseases or immune-related diseases such as systemic lupus erythematosus, asthma, inflammatory bowel disease, gout, and malignant tumor, etc;
• Pre-existing or plan for the administration of nonsteroidal anti-inflammatory drugs, hormones, immunomodulatory drugs, or chemotherapeutic drugs;
• Pregnant women, lactating women or women of childbearing age who do not use effective contraceptives;
• Any other circumstances in which the investigator judges that the patient is not suitable to participate in the clinical trial.