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NCT Number: NCT03927638

Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

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Key information

Conditions

Overweight and Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Montclair State University

Montclair, New Jersey, 07043, United States

About this study

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adult

Exclusion criteria

  • Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
  • Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
  • Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
  • Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
  • Are pregnant or trying to become pregnant.
  • Are not between 18 and 50 years of age.

Treatment and study plan

sit/stand

Behavioral

Subjects will be asked to both sit and stand during a single trial.

Primary outcomes

  1. Heart Rate

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.

  2. Systolic Blood Pressure (SBP)

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.

  3. Diastolic Blood Pressure (DBP)

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.

  4. Oxygen Consumption

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Oxygen consumption will be measured using indirect calorimetry.

  5. Carbon Dioxide Production

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Carbon Dioxide will be measured using indirect calorimetry.

  6. Ventilation

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Ventilation will be measured using indirect calorimetry.

  7. Respiratory Exchange Ration (RER)

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.

Secondary outcomes

  1. Height

    Time frame: 1 minute

    Standard stadiometer will be used to measure height in meters.

  2. Weight

    Time frame: 1 minute

    Standard scale will be used to measure weight in kilograms.

  3. Body Mass Index (BMI)

    Time frame: 1 minute

    Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.

  4. Body Composition

    Time frame: Approximately 15 minutes

    Body composition will be measured using air displacement plethysmography.

  5. Total Peripheral Resistance (TPR)

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.

  6. Stroke Volume

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.

  7. Cardiac Output (Q)

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.

  8. Muscle Oxygen Saturation

    Time frame: Approximately 15 minutes in each condition (sitting and standing)

    Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.

Sponsors and collaborators

Lead sponsor

Montclair State University

Other

Registry information

Important dates

Study start
2018
Primary completion
2028
Study completion
2028
First posted
Apr 25, 2019
Registry last updated
Jan 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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