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Completed

NCT Number: NCT03520192

Differences in Access to Emergency Paediatric Intensive Care and Care During Transport

There are fewer than 30 paediatric intensive care units (PICUs) in the United Kingdom (UK). This means that a critically ill child taken to their nearest hospital will need to be transferred to a PICU. Such transports are usually done by PICU retrieval teams (PICRTs), mobile teams who take specialist expertise to the child and safely transport them to a PICU.

There are national variations in how PICRTs are organised and deliver clinical care. There has been little research into these differences and how they might influence outcomes and experiences for sick children and families. The investigators do not know if national variation in how PICRT services are organised and delivered matters, or whether current standards help achieve the best outcomes for patients. This clinical study aims to understand how existing differences in access to paediatric intensive care and care provided by PICRTs affect clinical outcomes and experiences for transported critically ill children and families. The investigators will analyse routine national audit data to examine various aspects such as how long it takes a PICRT to reach the patient, how long it takes the child to reach the PICU, the seniority of clinicians performing the transport, medical procedures performed by the PICRT and any critical incidents during transport, and investigate whether any of these factors influence how likely a child is to survive. The investigators will also collect and analyse information about the experiences of sick children by interviewing the families involved, and staff experiences of PICU retrieval by interviewing clinicians. Alongside this work, the investigators will look at the costs of different ways of delivering PICRT services for sick children, and use mathematical techniques to study if and how alternate models of service delivery can improve clinical outcomes in a cost effective manner. The research team in this trial includes PICU and transport clinicians, parents, academic experts and an National Health Service (NHS) commissioner.

Independent committees consisting of clinicians and parents will be formed to oversee the study. The work from this study will directly inform the development of evidence-based national standards for PICU transport and help improve the patient experience for critically ill children and their families.

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Key information

Age range

Up to 16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Great Ormond Street Hospital for Children NHS Foundation Trust

London, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children and young people (age <16 years) transported by a PIC retrieval team for emergency admission to a paediatric intensive care unit in England and Wales.

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Mortality

    Time frame: 30 days

    Number

Secondary outcomes

  1. Mortality

    Time frame: up to 90 days

    Number

  2. Mortality

    Time frame: 90 days

    Number

  3. Mortality

    Time frame: One year

    Number

  4. Length of stay

    Time frame: up to 90 days

    Number (days)

  5. Days on invasive ventilation

    Time frame: up to 90 days

    Number (days)

  6. Vasoactive agent therapy

    Time frame: up to 90 days

    Number (days)

  7. Renal replacement therapy

    Time frame: up to 90 days

    Number (days)

  8. Extra-corporeal life support

    Time frame: up to 90 days

    Number (days)

  9. Length of hospital stay

    Time frame: up to 90 days

    Number (days)

  10. Number of hospital admissions

    Time frame: One year

    Number

  11. Days in hospital

    Time frame: One year

    Number (days)

Sponsors and collaborators

Lead sponsor

Great Ormond Street Hospital for Children NHS Foundation Trust

Other

Registry information

Official study title

Critically Ill Children and Young People: do National Differences in

Acronym: DEPICT

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
May 9, 2018
Registry last updated
Oct 4, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.