CHU Saint-Etienne
Saint-Etienne, 42000, France
NCT Number: NCT04511858
The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.
Looking for future studies?
Notify Me18 year and older
Male
Interventional
Not applicable
Saint-Etienne, 42000, France
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
5 h test on cycloergometer
5 h test on treadmill
Time frame: Before and immediately after 5h exercise
measured in isometric mode of the knee extensors, between the value before and immediately after a 5-hour cycling or running event at the same relative intensity
Time frame: Before and immediately after 5h exercise
measured in isometric mode of the knee extensors, between the value before the 5h cycling or running and the value after absolute exhaustion
Time frame: Before and immediately after 5h exercise
tests with measurement of the maximum voluntary with evoked electrical between the value before and immediately after a 5-hour cycling or running event at the same relative intensity
Time frame: Before and immediately after 5h exercise
thoracic spine stimulation for the recording of thoracic motor evoked potentials
Time frame: Before and immediately after 5h exercise
stimulation of the motor cortex for recording motor evoked potentials
Time frame: Before and immediately after 5h exercise
ratio between stimulation of the motor cortex and thoracic spine stimulation
Time frame: Before and immediately after 5h exercise
subjects sitting on a Cybex type seat, with the knee and hip angle set at 90°. The foot will be attached to a strain-gauge sensor using a velcro strap attached to the ankle above the medial malleolus.
Time frame: Before and immediately after 5h exercise
assessment of fatigue in dynamic mode (calculation of the force/speed profile)
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
blood sample
Time frame: Before and immediately after 5h exercise
On treadmill
Time frame: Before and immediately after 5h exercise
On Cycloergometer
Centre Hospitalier Universitaire de Saint Etienne
Other
Acronym: FAT-CENTR
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT04025138
Ultra-marathon Runners
Saint-Etienne, France
View Trial Details