Dietry Pattern and Lead Levels in Pregnancy

During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.

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Key information

Conditions

Dietary Habits Behavior Behavior, Animal Chemically-Induced Disorders Feeding Behavior Heavy Metal Poisoning Lead Poisoning Poisoning Pregnancy Related

Sex eligibility

Female

Study type

Observational

About this study

Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Enrolled in ALSPAC, pregnant -

Exclusion criteria

Not enrolled in ALSPAC, not pregnant

Treatment and study plan

None - Observational

Other

None - observational

Primary outcomes

Blood lead concentration

Time frame: During gestation

Blood lead concentration

Sponsors and collaborators

Lead sponsor

University of Bristol

Other

Collaborators

Bristol Biomedical Research Unit
Medical Research Council
Wellcome Trust

Registry information

Official study title

Dietary Patterns and Variability in Blood Lead Concentrations Among Pregnant British Women

Important dates

Study start: 1991
Primary completion: 1992
Study completion: 1992
First posted: Jan 23, 2018
Registry last updated: Jan 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed