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NCT Number: NCT06828159

Dietary Wild Blueberries and Joint Health

The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

Recruiting

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Key information

Conditions

Gut -Microbiota Arthralgia Inflammation Biomarkers Joint Diseases Joint Pain Musculoskeletal Diseases Neurologic Manifestations Pain Pain Assessment Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

40 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults with documented multi-joint/knee arthritis

Exclusion criteria

  • inability to give informed consent
  • pregnancy or lactation
  • planned knee replacement surgery
  • allergy or contraindication to berries
  • recent trauma of the knee responsible of the symptomatic knee
  • intra-articular injection in the target knee/hip in the last 3 months
  • oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
  • use of berry extracts in the last 3 months
  • special diets
  • cancer treatment
  • bone diseases

Treatment and study plan

Wild Blueberry

Dietary Supplement

Freeze-dried wild blueberry powder 25g/day

Placebo

Dietary Supplement

Placebo powder matched for calories and no polyphenols

Primary outcomes

  1. Serum biomarkers of joint function

    Time frame: 12 weeks

    Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.

Secondary outcomes

  1. Gut microbiome

    Time frame: 12 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Arpita Basu

CONTACT

[email protected]

702-895-4576

Sponsors and collaborators

Lead sponsor

University of Nevada, Las Vegas

Other

Collaborators

  • Oklahoma Medical Research Foundation

Registry information

Official study title

Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Feb 14, 2025
Registry last updated
Nov 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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