Dietary Salt Intake and Vascular Function

Healthy volunteers will be enrolled in a dietary sodium intervention to examine impact on vascular function.

Inclusion criteria

• Healthy male, African-American volunteers
• 18-35 years of age,
• No personal or first degree relative with hypertension or diabetes,
• Blood pressure <130/85 mmHg and > 90/60 at the screening visit,
• Body mass index <30 kg/m2,
• No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).

Exclusion criteria

• Alcohol intake >2 beverage/night,
• Smoking,
• Recreational drug use,
• Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months,
• Prescription or herbal medication use,
• Ischemic changes on resting electrocardiogram,
• Known hypersensitivity to any of the study drugs,
• Other active medical problems detected by examination or laboratory testing.