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Completed

NCT Number: NCT03659890

Dietary Nucleotides and Ribose on Muscle Fuel Utilisation

Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.

Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.

This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter - St Luke's Campus

Exeter, Devon, EX2 4TH, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30

Exclusion criteria

  • On medication (except contraception)
  • Smokers
  • Diagnosed with any metabolic or cardiovascular conditions
  • Muscle or bone injuries
  • BMI < 18 or > 30

Treatment and study plan

Low nucleotide

Dietary Supplement

2 week, twice daily, supplementation with a nucleotide-depleted mycoprotein drink, with added dextrose

High nucleotide

Dietary Supplement

2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added dextrose

High nucletide + Ribose

Dietary Supplement

2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added ribose

Primary outcomes

  1. Changes in muscle ATP concentrations

    Time frame: After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery

Secondary outcomes

  1. Changes in muscle glycogen concentrations

    Time frame: After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery

  2. Blood lactate concentrations

    Time frame: After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise

  3. Blood glucose concentrations

    Time frame: After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise

  4. Serum uric acid concentrations

    Time frame: Measured at baseline and of days 6, 8 and 15 of each supplementation cycle

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

The Effect of Dietary Nucleotides and Ribose on Muscle Fuel Utilisation and Exercise Performance

Acronym: FUN

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Sep 6, 2018
Registry last updated
Mar 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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