Sport and Health Sciences, University of Exeter
Exeter, Devon, EX12LU, United Kingdom
NCT Number: NCT03473678
This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days
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Notify Me70 year–80 year
All sexes
Interventional
Not applicable
Exeter, Devon, EX12LU, United Kingdom
A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
concentrated beetroot juice
concentrated beetroot juice
Time frame: 10 days
Change in blood pressure between interventions
Time frame: 10 days
Change in oxygen consumption during exercise
Time frame: 10 days
change in performance of the Serial Subtraction test
Time frame: 10 days
change in oral microbiome measured by sequencing bacterial 16S rRNA genes
Time frame: 10 days
change in brain metabolites measured measured by 1H MRS
Time frame: 10 days
change in performance of 6 minute walk test
University of Exeter
Other
Influence of Dietary Nitrate Supplementation on Blood Pressure, Walking Economy, Functional Physical Capacity and Cognitive Function in Healthy Older Adults
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