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Completed

NCT Number: NCT03473678

Dietary Nitrate and Healthy Older Adults

This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days

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Key information

Age range

70 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sport and Health Sciences, University of Exeter

Exeter, Devon, EX12LU, United Kingdom

About this study

A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 70 - 80 years of age
  • male or female

Exclusion criteria

  • involved in regular structured exercise
  • receiving medication for:
  • pulmonary conditions
  • cardiovascular conditions
  • metabolic conditions
  • musculoskeletal conditions
  • ulcerative colitis
  • renal disease

Treatment and study plan

Nitrate-rich beetroot Juice

Dietary Supplement

concentrated beetroot juice

Nitrate-depleted beetroot juice

Dietary Supplement

concentrated beetroot juice

Primary outcomes

  1. Blood pressure

    Time frame: 10 days

    Change in blood pressure between interventions

Secondary outcomes

  1. Oxygen cost of exercise

    Time frame: 10 days

    Change in oxygen consumption during exercise

  2. Serial Subtraction test

    Time frame: 10 days

    change in performance of the Serial Subtraction test

  3. Microbiome

    Time frame: 10 days

    change in oral microbiome measured by sequencing bacterial 16S rRNA genes

  4. Brain metabolism

    Time frame: 10 days

    change in brain metabolites measured measured by 1H MRS

  5. 6 minute walk test

    Time frame: 10 days

    change in performance of 6 minute walk test

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

Influence of Dietary Nitrate Supplementation on Blood Pressure, Walking Economy, Functional Physical Capacity and Cognitive Function in Healthy Older Adults

Important dates

Study start
2014
Primary completion
2015
Study completion
2018
First posted
Mar 22, 2018
Registry last updated
Mar 22, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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