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OpenTrials
Completed

NCT Number: NCT01006174

Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

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Key information

Conditions

Absorption of Carotenoids From Vegetables

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Purdue University

West Lafayette, Indiana, 47906, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range: 18-50 years.
  • Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
  • Weight stable (<4.5 kg change within the last 3 months),
  • Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
  • Must be pre-menopausal
  • Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
  • Non-smoking
  • Non-diabetic
  • No current or planned pregnancy
  • Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
  • No current use of medication affecting lipid profile
  • No intestinal disorders including lipid malabsorption, lactose intolerance
  • No heavy consumption of alcohol (>2 drinks per day)
  • No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion criteria

  • Menopausal
  • Diabetic
  • Currently pregnant
  • Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
  • Use of lipid altering medications

Treatment and study plan

soybean oil

Other

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Canola Oil

Other

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

Butter

Other

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

Primary outcomes

  1. Evaluating the impact of dietary lipid profiles on intestinal absorption of carotenoids from vegetables.

    Time frame: 66 days

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Registry information

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Nov 2, 2009
Registry last updated
Jan 17, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.