Diet Treatment of Patients With Ulcerative Colitis in Remission

Patients are randomized to either standard care, low FODMAP diet or a normal FODMAP diet. Run-in on a low FODMAP diet, thereafter parallel design where one arm is assign a blinded food supplement with low FODMAP content and the other arm is assigned a blinded food supplement containing FODMAP. A control group is "watchful waiting".

Symptom reports, blood, and fecal samples are collected.

Inclusion criteria

• Colitis ulcerosa in remission (calciprotectin<200 and normal sigmoidoscopy)
• ROM IV criteria fullfilled
• Stable medical therapy

Exclusion criteria

• Intake of a low FODMAP diet within the past 6 weeks prior to baseline
• Atypical colitis ulcerosa primarily right sided disease and calciprotectin >50 unless normal sigmoidoscopy
• If diarrhea: Clostridium difficile infection
• Lactose intolerance
• Systemisk or local treatment for CU other than 5-aminosalicylicacid or biological therapy
• Antibiotics within 6 weeks
• Pregnancy
• Activity in UC
• Coeliac disease
• Abnormal transglutaminase
• Eating disorder
• Special diet preventing the low FODMAP diet
• Other GI disease or other disease explaining symptoms
• Medication intake explaining symptoms
• Not able to follow protocol