Diet, Obesity and Genes (DiOGenes)

DiOGenes is a randomised controlled dietary intervention study in obese/overweight families (adults and children) in 8 different European countries, testing the efficacy and safety of diets differing in Glycaemic Index (GI) and protein content.

The 8 centres are divided into "shop centers" and "instruction centers", that provide different kind of dietary intervention and for a different length(see below):

The 2 Shop Centers (Denmark & The Netherlands):

Dietary periods and clinical examinations:

• Clinical examination 1 with anthropometry, blood etc.
• 8 week Low Calorie Diet (LCD) period (800-1000 kcal/day)(Adults only)
• Clinical examination 2 with anthropometry, blood etc.
• 6 months dietary intervention period 1 (SUPERMARKET period)(Family)
• Clinical examination 3 with anthropometry, blood etc.
• 6 months dietary intervention period 2 (DIETARY INSTRUCTION period)(Family).
• Clinical examination 4 with anthropometry, blood ect.
• 12 months free-living period with no dietary intervention. (Family)
• Follow up (only body weight registration)

The 6 Instruction Centers (UK, Crete, Germany, Spain, Bulgaria, Czech Republic)

Dietary periods and clinical examinations:

• Clinical examination 1 with anthropometry, blood etc.
• 8 week Low Calorie Diet (LCD) period (800-1000 kcal/day). (Adults only)
• Clinical examination 2 with anthropometry, blood etc.
• 6 months dietary intervention period (DIETARY INSTRUCTION period). (Family)
• Clinical examination 3 with anthropometry, blood etc.
• 6 months free-living period with no dietary intervention. (Family)
• Follow up (only body weight registration)

Note that, during the first 6 month intervention all families from the shop centers are provided all foods free of charge "SUPERMARKET PERIOD", whereas in the "Instruction Centers", the families receive dietary instruction only "Instruction Only".

Inclusion criteria

• Families with healthy adults and children

Exclusion criteria

• Various