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OpenTrials
Completed

NCT Number: NCT00188903

Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery

Left ventricular (LV) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.It is present when the ventricular filling is impaired as a result of delayed relaxation or decreased compliance. During Coronary artery bypass grafting (CABG) surgery, LV diastolic dysfunction is a frequent occurrence. Failure of the left ventricle to dilate normally causes an increase in LV filling pressure. Atrial fibrillation (AF) is a common complication after cardiac surgery affecting 20-30% of patients undergoing coronary revascularization procedures. AF is associated with significant morbidity and mortality and has been identified as a causative factor of increased length of both hospital and intensive care unit (ICU) stay after CABG surgery, resulting in increased resource utilization and medical care costs.The primary aim of this study is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of AF after coronary revascularization surgery.

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Key information

Conditions

Heart Disease Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • scheduled for elective CABG or OPCAB surgery
  • signed informed consent

Exclusion criteria

  • Patients with a history of previous heart surgery and/or undergoing valvular heart surgery.
  • Patients with preoperative atrial fibrillation.
  • Patients in whom TEE is contraindicated.

Treatment and study plan

Diastolic measurements during TEE

Procedure

Transesophageal echocardiography with diastolic measurements

Primary outcomes

  1. Is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of AF after coronary revascularization surgery.

    Time frame: pre and post operative

Secondary outcomes

  1. Is to determine if diastolic dysfunction and AF are associated with increased perioperative cardiac morbidity and reduced event-free survival.

    Time frame: post operative until discharge

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Registry information

Official study title

Diastolic Dysfunction and Atrial Fibrillation in Patients Undergoing Coronary Revascularization Surgery

Important dates

Study start
2004
Primary completion
2007
Study completion
2010
First posted
Sep 16, 2005
Registry last updated
Aug 5, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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