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OpenTrials
Completed

NCT Number: NCT00786526

Diaphragmatic Function in Ventilated Patients

Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).

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Key information

Conditions

Critically Ill Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesia and Critical Care (DAR B), Saint-Eloi University Hospital of Montpellier, Montpellier, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
  • Duration of mechanical ventilation for at least 72h.·
  • Subject itself or its next of kin has given written informed consent

Exclusion criteria

  • Patient is less than 18 years or more than 85 years of age·
  • The attending physician refuses to allow enrollment·
  • The patient refuses informed consent
  • Next of kin is unavailable or refuses informed consent·
  • Pregnant or breast-feeding female.
  • A pregnancy test will be performed in all female patients less than 60 years of age.·
  • Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).·
  • Presence or suspicion of prior diaphragm injury or chronic disease·
  • Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection

Treatment and study plan

Primary outcomes

  1. Respiratory function parameters

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Ventilator-Induced Diaphragmatic Dysfunction (VIDD) in Critically Ill Patients

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Nov 6, 2008
Registry last updated
Oct 30, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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