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OpenTrials
Completed

NCT Number: NCT02403765

Diagnostic Tools for Parkinson's Disease

The study aims to identify genetic variants associated to Parkinson's disease through the analysis of exome-sequencing data of familial cases and controls. The identified variants will be used to generate a diagnostic tool for the identification of genetic risk profiles.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Neuromed

Pozzilli, 86077, Italy

About this study

  • Clinical evaluation of PD patients and relatives
  • High throughput analysis of genetic variants in genome exomes
  • Genotype-phenotype association testing
  • Identification of genetic risk variants for PD

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of at least two out the following cardinal signs: resting tremor, cogwheel rigidity, bradykinesia, asymmetrical onset of symptoms and symptomatic response to L-dopa (levodopa)

Exclusion criteria

  • Previous thalamotomy on the implanted sided, significant brain atrophy or structural damage seen on CT or MRI, marked cognitive dysfunction, active psychiatric symptoms, or concurrent neurological or other uncontrolled medical disorders.

Treatment and study plan

Primary outcomes

  1. Identification of genetic variants associated with Parkinson's disease

    Time frame: Two years

    Analysis of exome sequencing data; annotation of genetic variants; selection of variants present in cases and absent in controls

Sponsors and collaborators

Lead sponsor

Neuromed IRCCS

Other

Registry information

Official study title

Realization of Diagnostic Tools for the Early Analysis of Parkinson's Disease Through the Identification of Genetic Risk Profiles

Important dates

Study start
2015
Primary completion
2018
Study completion
2019
First posted
Mar 31, 2015
Registry last updated
Nov 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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