Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease

Inclusion criteria

• Patients between 40 and 85 years old,
• French native language,
• Social Security affiliation.
• University Memory Clinic for: Mild severity disorder (MMSE> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011
• to MCL according to McKeith criteria
• to FTLD according to Rascovsky 2011 criteria
• BBD according to Armstrong's criteria
• related to PSP according to Höglinger criteria

Exclusion criteria

• Mental retardation or guardianship
• Previously diagnosed dementia
• Other current or past brain condition
• severe head trauma
• epilepsy prior to stroke still requiring previous treatment
• Parkinson disease, multiple sclerosis...
• brain tumor or brain radiation therapy
• Current or past schizophrenia or psychosis
• Active or past psychiatric disorders requiring a stay> 2 days in a specialized environment
• Contra indication to MRI
• Comorbidity with life expectancy <1 year
• Comorbidity affecting cognition in particular:
• Alcohol (> 3 glasses / day) or history of alcohol withdrawal syndrome
• opiate or cocaine addiction or opiate withdrawal syndrome
• renal failure (dialysis or creatinine clearance <30)
• hepatic failure (spontaneous INR> 1.5 or PT <60%)
• respiratory failure requiring oxygen therapy
• heart failure (orthopnea> 2 pillows)
• persistent vigilance disturbances (NIHSS1a score ≤1)
• cancer with paraneoplastic syndrome
• treatment with gold salts, D Penicillamine or other treatment with cognitive effect
• Patient under guardianship or curators or private under public law
• Pregnant and / or lactating wom