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OpenTrials
Completed

NCT Number: NCT00855231

Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain

The ACUTE CT trial is designed to test whether the assessment of chest structures by high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy for patient with acute chest pain or other potential cardiac symptoms as compared to a standard of care evaluation.

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Key information

Conditions

Chest Pain Acute Aortic Syndrome Acute Coronary Syndrome Aneurysm Aortic Diseases Aortic Dissection Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Dissection, Blood Vessel Embolism Embolism and Thrombosis Heart Diseases Lung Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Pulmonary Embolism Respiratory Tract Diseases Signs and Symptoms Vascular Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Washington Medical Center

Seattle, Washington, 98195, United States

About this study

Adults at low to intermediate risk of acute coronary syndrome who present to the Emergency Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT (coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will be collected and compared to a CT-based evaluation. Patients will be followed for 3 years after enrollment to evaluate prognosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Low to intermediate risk of angina with a TIMI ACS Risk Score ≤ 4
  • chest pain or other symptoms suggestive of ACS within 24 hours
  • male ≥30 years or female ≥45 years old
  • at least one cardiac risk factor
  • no obvious cause for symptoms.

Exclusion criteria

  • known CAD
  • ST segment elevation, new left bundle branch block or dynamic ECG changes
  • creatinine ≥1.8 g/dL
  • pregnant or lactating female
  • hemodynamic or respiratory instability
  • ongoing bronchospasm
  • known iodinated contrast allergy
  • atrial fibrillation or irregular heart rate

Treatment and study plan

Primary outcomes

  1. Diagnostic accuracy of CT compared to standard of care evaluation

    Time frame: 3 months

Secondary outcomes

  1. Cost savings of CT-based evaluation compared to the standard of care evaluation

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • GE Healthcare

Registry information

Official study title

Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain - Assessment of Chest Pain Utilizing a Triple Rule Out Evaluation With Computed Tomography (ACUTE CT) Trial

Acronym: ACUTE CT

Important dates

Study start
2006
Primary completion
2009
Study completion
2009
First posted
Mar 4, 2009
Registry last updated
Nov 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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