Diagnosis, Prognosis, and Mechanisms in Panvascular Disease

Panvascular diseases are a group of complex disorders affecting the entire vascular system, with their development influenced by multiple risk factors, including genetic susceptibility, metabolic abnormalities (such as hypertension, hyperlipidemia, and diabetes), inflammatory responses, oxidative stress, and unhealthy lifestyle habits (such as smoking and physical inactivity). In-depth research into the mechanisms of these factors can help uncover the core drivers of the disease, providing a theoretical foundation for early prevention and intervention. Additionally, elucidating specific molecular pathways (such as inflammatory signaling, lipid metabolism, and endothelial dysfunction-related pathways) and molecular regulatory mechanisms (such as non-coding RNAs and epigenetic modifications) can offer new targets for precise diagnosis and treatment. By integrating multi-omics data and high-throughput technologies, the molecular networks of panvascular diseases can be systematically clarified, advancing the development of personalized medicine. This will significantly improve patient outcomes, reduce disease burden, and hold substantial scientific value and clinical application prospects.

This study aims to establish a standardized cohort for panvascular diseases, encompassing various biological materials such as DNA samples, as well as comprehensive patient medical records and long-term follow-up information. The database will systematically collect multidimensional data, including patient questionnaire data (e.g., lifestyle, family history, dietary habits), imaging examination results (e.g., ultrasound, CT, MRI), DNA and other biochemical indicators extracted from blood samples, as well as non-invasive physiological parameters such as blood pressure and heart rate, and examinations related to arterial health assessment (e.g., pulse wave velocity, ankle-brachial index). By integrating these multi-source data, researchers will be able to conduct in-depth analyses of the genetic, metabolic, and clinical characteristics of panvascular diseases, identify disease-related biomarkers and predictive factors, and thereby provide a valuable resource for investigating the mechanisms of panvascular diseases.

Based on this database, researchers can systematically explore the risk factors of panvascular diseases and their dynamic evolution patterns, uncovering the key driving mechanisms behind disease development. Furthermore, through high-throughput sequencing, multi-omics analysis, and machine learning technologies, researchers can identify potential molecular targets and therapeutic strategies, advancing the field of precision medicine. These research outcomes will not only contribute to the development of novel diagnostic methods and personalized treatment plans but also provide a scientific basis for the early prevention and intervention of panvascular diseases, ultimately improving patient prognosis and reducing disease burden. The establishment of this resource platform will provide critical support for research and clinical practice in panvascular diseases, holding profound scientific significance and practical value.

Inclusion criteria

• Male or female aged 18 to 80 years old;
• Diagnosed or suspected panvascular disease, defined as the presence of atherosclerotic lesions in at least two or more vascular regions, such as intracranial arteries, carotid arteries, coronary arteries, aorta, and peripheral arteries;
• Voluntary participation in this study and provision of signed informed consent.

Exclusion criteria

• Severe hemodynamic instability;
• Severe cardiac dysfunction (EF < 30%);
• Severe arrhythmias;
• Severe valvular heart disease;
• Cardiomyopathy caused by non-coronary artery diseases;
• Non-atherosclerotic coronary artery disease (e.g., coronary artery dissection, embolism, etc.);
• Severe non-cardiovascular diseases;
• Women who are pregnant or breastfeeding;
• Individuals who refuse to provide signed informed consent.