Skip to main content
OpenTrials
Enrolling by Invitation

NCT Number: NCT07030023

Diagnosis of Wire Syndrome

The Wire Syndrome (WS) refers to aberrant, unexpected, unexplained, or excessive dental movements involving teeth held by an intact post-orthodontic retention wire. Its prevalence ranging from 1.1% to 43%. It is a chronic, progressive pathological process, generally asymptomatic, resulting in a new malocclusion that is not due to relapse or a physiological process, and whose aesthetic and/or functional dento-periodontal consequences are harmful. The causes are multifactorial origin. In the early stages of Wire Syndrome, dental and periodontal consequences are minors. These issues are thought to progressively worsen over time.However, to date, no author has proposed an appropriate diagnostic approach. Indeed, several diagnostic criteria have been reported in the literature, but their hierarchical ranking, in terms of importance and specificity, has yet to be determined.

The main objective of this study is therefore to propose a classification of WS according to its severity, based on a shared framework between periodontists and orthodontists. This classification should, facilitate early detection of the syndrome, and reduce diagnostic delays and therapeutic errors. It should also help clarify prognosis and improve interprofessional collaboration in developing personalized treatment plans.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU NICE

Nice, Alpes Maritimes, 06 000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of fixed orthodontic retention (maxillary and/or mandible)
  • Comprehensive documentation available
  • Systemically healthy
  • Presence or not of a Wire Syndrome

Exclusion criteria

  • Patient with other orthodontic retention.
  • Patient unable to understand french

Treatment and study plan

Non intervention

Other

Non intervention

Primary outcomes

  1. Presence of Wire Syndrome

    Time frame: At the inclusion

    The presence of Wire Syndrome was clinically evaluated (based on photographs) under 2 answers "Yes" or "No".

  2. severity classification of Wire Syndrome

    Time frame: At the inclusion

    Severity was categorized into three grades such as minor, moderate, and severe based on dental and periodontal parameters.

Secondary outcomes

  1. Major clinical diagnosis criteria (Fleiss Kappa)

    Time frame: At the inclusion

    Fleiss Kappa coefficient : minimum value : <0 = no aggreeement; maximum value : > 0.8 = almost perfect.

  2. Minor clinical diagnostis criteria (Fleiss Kappa)

    Time frame: At the inclusion

    Fleiss Kappa coefficient : minimum value : <0 = no aggreeement; maximum value : > 0.8 = almost perfect.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

How to Diagnose Wire Syndrome ? A Classification Based on Retrospective Studies and Clinical Experience

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 19, 2025
Registry last updated
Jun 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.