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OpenTrials
Completed

NCT Number: NCT00593216

Diagnosis Of Vertigo With New Imaging

The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.

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Key information

About this study

The incidence of vertigo has been reported to be as high as 1.5% in the general population and some reports suggest that more than 5% of adults experience some kind of vertigo each year. In 80% of affected individuals, this symptom resulted in a medical consultation, interruption of daily activities, or sick leave. Therefore, vertigo can have a significant impact on health and well being. Unfortunately, there is not yet any satisfactory objective method for diagnosis of vertigo. At present, the diagnosis usually depends on medical history, vestibular function tests, Dix-Hallpike positioning tests done in the office, and, to some extent imaging studies doen to look for such abnormalities such as acoustic tumor, brain tumor, and evidence of multiple sclerosis. A number of recent studies support the possibility of using functional MRI (fMRI), particularly a new diffusion tensor fiber tracking (DTT) technique, as a new tool for diagnosis of disorders that can cause vertigo. In this study, our hypothesis is that there is an alteration in the activity in neural pathways of patients with vertigo that can be detected by fMRI. To test this assumption, our objective in this study is to determine whether there is a difference between the fMRI images obtained in normal subjects versus those in patients with vertigo.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteer or patient with symptom of vertigo

Exclusion criteria

  • Evidence of mental impairment
  • Any type of bioimplant or any type of ferromagnetic bioimplant
  • Pregnant females
  • Exhibit noticeable anxiety and/or claustrophobia
  • History of serious disease in central nervous and cerebrovascular systems.

Treatment and study plan

Functional MRI imaging

Device

The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.

Other names: Magnetic Resonance Imaging

Primary outcomes

  1. Activation of target sites on the functional MRI images during the vestibular response

    Time frame: Not specific

Secondary outcomes

  1. Differences in the fiber tracking of central nervous system specifically involved in the vestibular response

    Time frame: Not specific

Sponsors and collaborators

Lead sponsor

Boston University

Other

Registry information

Official study title

New Diagnosis Of Vestibular Vertigo With Functional MRI

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Jan 14, 2008
Registry last updated
Jun 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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