Diabetic Ketoacidosis and Its Impact on the Brain

Participant Schedule:

• One visit for 3-4 hours at the Stanford Medical Center to complete neuropsychological testing and to become familiar with the MRI scanner.
• Subjects who need to become more familiar with the MRI scanning process will view a video tape at home.
• One visit for 1-2 hours at Stanford Medical Center to have the MRI scan of the head completed.
• Subjects between 10 and 17 years of age will also be asked to complete two additional abbreviated neuropsychological tests at one week and one month from enrollment.
• Subjects may have the complete neuropsychological testing and MRI scan repeated 15 months from time of enrollment.

Inclusion criteria

To take part in the study, the participant must meet the following inclusion criteria:

• Be between the ages of 4 to 17 years.
• Either has been diagnosed with type 1 diabetes mellitus OR does not have type 1 diabetes mellitus

Exclusion criteria

If the interested participant has a history of head trauma with any loss of consciousness, prematurity (born less than 30 weeks of gestation), significant developmental delay (lack of single word speech or ability to walk independently by 18 months of age), neurologic disease independent of diabetes (eg seizure disorder or medical contraindication to MRI procedure (eg metal appliances such as braces).