Diabetes Registry Graz for Biomarker Research

Obesity and diabetes represent probably the most challenging threat to public health in the 21st century.

Despite well-controlled established cardiovascular risk factors, the residual risk in subjects with diabetes mellitus is significantly higher than the risk in those without the condition and it is well established that current risk prediction models for cardiovascular disease using established risk factors do not fully explain the future cardiovascular risk.

Therefore, biomarker for better risk stratification are needed, in particular in subjects with diabetes mellitus. Prospective cohorts, meticulously clinically phenotyping subjects, regularly following them and collecting biomarker samples is one key approach for finding new biomarker panels, that are predictive of treatment response and future micro- and macrovascular complications.

The Diabetes registry for Biomarker Research Graz was initiated in November 2015. Subjects with type 1 and type 2 diabetes, rare types of diabetes, obesity or dyslipidemia are recruited in the outpatient clinic for Diabetes, Lipid and Metabolic Disorders at the University Clinic Graz or in the Rehabilitation Center St. Radegund.

As of September 2021, 1250 subjects are recruited. Blood and urine samples samples are collected at baseline and at annual follow up visits as well as data on medical history, diagnoses and medication.

Inclusion criteria

• 18 - 99 years
• Informed consent has to be given in written form
• At least one of the following diseases:
• Type 1 diabetes
• Type 2 diabetes
• Type 3 diabetes
• Maturity onset diabetes of young (MODY)
• Late onset diabetes of the adult (LADA)
• Adipositas (BMI > 30kg/m2)
• Lipid metabolism disorder

Exclusion criteria

• No written informed consent
• No willingness to participate in this registry