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NCT Number: NCT07611890

Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial

After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.

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Key information

Conditions

Laryngoscopic Stress Response Dexmedetomidine Lignocaine

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Rawalpindi Institute of Cardiology

Rawalpindi, Punjab Province, 46000, Pakistan

Location status: Recruiting

Location contact

Asma Shabbir, MBBS,FCPS

CONTACT

[email protected]

+92 333 5161142

About this study

After confirming eligibility, written informed consent will be obtained and each participant will be assigned a unique study ID to maintain confidentiality. Participants will be randomly allocated using a computer-generated random sequence implemented through the lottery method, with assignments placed in sealed opaque envelopes opened on the day of surgery. The study medication will be administered intravenously according to the study protocol before laryngoscopy and endotracheal intubation. Mean arterial pressure and heart rate will be recorded at baseline and at 1, 3, 5, and 10 minutes after intubation. Demographic information and study-related observations will be documented in a structured data collection form.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events

Exclusion criteria

  • Patients with known hypersensitivity to dexmedetomidine and Lignocaine.
  • Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).
  • Pregnant or lactating women.
  • Patients with a history of airway anomalies or difficult intubation.

Treatment and study plan

IV dexmedetomidine

Drug

0.5 Mcg/kg of Dexmedetomidine will be given 10 minutes before laryngoscopy

IV Lignocaine

Drug

Patients will be given 1.5 mg/kg of Lignocaine 3 minutes before laryngoscopy

Primary outcomes

  1. Mean Arterial Pressure

    Time frame: It will be expressed in millimeters of mercury (mmHg) and measured using an arterial catheter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.

  2. Heart Rate

    Time frame: It will be expressed as number of heart beats per minute and measured using pulse oximeter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.

Study contacts

Contact information is provided by the study sponsor or research team.

Namrah Zujaj, MBBS

CONTACT

[email protected]

+92 305 2636980

Sponsors and collaborators

Lead sponsor

Rawalpindi Institute of Cardiology

Other

Registry information

Official study title

Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 28, 2026
Registry last updated
May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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