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OpenTrials
Completed

NCT Number: NCT07048873

Dexmedetomidine Versus Ketamine on Laryngeal Microsurgery

compare effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and detect side effects of dexmedetomidine and ketamine.

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Key information

Conditions

Microlaryngeal Surgery

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine Cairo university

Cairo, Egypt

About this study

Microlaryngeal surgery is a common surgical procedure now a days which is associated with many complications such as postoperative pain, airway edema and persistent cough

. the study is to compare the effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and to detect side effects of dexmedetomidine and ketamine.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged 18-70 years ASA I,II

Exclusion criteria

  • CVdiseases as IHD and severe valvular disease.
  • allergy to ketamine or dexmedetomidine.
  • Patients refusal
  • Suspected difficult intubation more than 2 trials

Treatment and study plan

Dexmedetomidine

Drug

IV dexmedetomidine

ketamine

Drug

IV ketamine

Saline (control group)

Drug

no drugs

Other names: NO drugs

Primary outcomes

  1. incidence of postoperative sore throat

    Time frame: 30 minutes postoperative

    incidence of postoperative sore throat

Secondary outcomes

  1. Ramsey sedation score

    Time frame: 1hour postoperative

    Ramsey sedation score RSS (1 to 6)

  2. postoperative cough incidence

    Time frame: 1hour postoperative

    postoperative cough incidence

  3. incidence of complications

    Time frame: 1hour postoperative

    incidence of complications

  4. Heart Rate

    Time frame: 1hour postoperative

    Heart Rate

  5. Mean Arterial Pressure

    Time frame: 1hour postoperative

    Mean Arterial Pressure

  6. oxygen saturation

    Time frame: 1hour postoperative

    oxygen saturation

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Dexmedetomidine Versus Ketamine on Patients of Laryngeal Microsurgery: a Randomized Controlled Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 3, 2025
Registry last updated
Jul 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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