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NCT Number: NCT07164326

Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients

Dexmedetomidine nebulization in sever preeclamptic patients

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Key information

Conditions

Pressor Response Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
  • ASA II, III

Exclusion criteria

  • sever obesity (BMI ≥ 40)
  • Cardiac patients
  • History of diabetes mellitus
  • Renal dysfunction (elevated serum creatinine > 2mg\\dl)
  • hepatic dysfunction (elevated hepatic enzyme three times above normal)
  • History to hypersensitivity to the tested drug.
  • Emergency surgery
  • Known fetal anomalies

Treatment and study plan

Dexmedetomidine

Drug

Nebulization of dexmedetomidine

Saline

Drug

Nebulization of normal saline

Primary outcomes

  1. Systolic blood pressure in response to endotracheal intubation

    Time frame: Intraoperative

    the change in systolic blood pressure in response to endotracheal intubation

Secondary outcomes

  1. Optic nerve sheath diameter

    Time frame: Intraoperative

    the change in optic nerve sheath diameter in response to endotracheal intubation

  2. Incidence of maternal postoperative sore throat

    Time frame: 1 hour Postoperative

  3. Incidence of maternal postoperative hoarseness of voice

    Time frame: 1 hour Postoperative

Study contacts

Contact information is provided by the study sponsor or research team.

Fatma Nabil

CONTACT

[email protected]

Mohamed S. Hussein

CONTACT

[email protected]

+201028586836

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients Undergoing Caesarean Section Under General Anaesthesia

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 10, 2025
Registry last updated
Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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