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Completed

NCT Number: NCT03355534

Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery

Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.

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Key information

Conditions

Aneurysm Cerebral Aneurysm Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Intracranial Aneurysm Intracranial Arterial Diseases Nervous System Diseases Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Xijing Hospital

Xi'an, Shaanxi, 710032, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients undergoing cerebral aneurysm embolism under general anesthesia

Exclusion criteria

  • patients with bradycardia or atrioventricular heart block
  • patients with ASA(American Society of Anesthesiologists) status over 3
  • patients with body mass index(BMI)≥30kg/m2
  • patients with difficulty in communication
  • patients with ruptured aneurysm
  • patients suspected or proved to be pregnant

Treatment and study plan

Intravenous dexmedetomidine

Drug

drug is intravenously infused to patients

nasal dexmedetomidine

Drug

drug is nasally given to patients

Intravenous saline

Drug

saline is given to patients intravenously

Nasal saline

Drug

normal saline is given to patients nasally

Primary outcomes

  1. incidence of coughing

    Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes

Secondary outcomes

  1. Ricker's agitation-sedation score

    Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes

  2. score of coughing

    Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes

    0=no coughing;1=intermittent coughing;2=continuous coughing

  3. time to response to verbal command

    Time frame: from end of infusing anesthetics to response to verbal command,averagely 20 minutes

  4. time to extubation

    Time frame: from end of infusing anesthetics to extubation,averagely 28 minutes

  5. blood pressure before and after extubation

    Time frame: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes

  6. blood glucose before and after aneurysm embolism

    Time frame: immediately before inserting coil and after finishing inserting coil,an average of 1 hour

  7. blood lactate before and after aneurysm embolism

    Time frame: immediately before inserting coil and after finishing inserting coil,,an average of 1 hour

  8. Mini-mental state examination score

    Time frame: 24 hours after surgery

Sponsors and collaborators

Lead sponsor

Zhihong LU

Other

Registry information

Official study title

Effect of Dexmedetomidine on Maintenance and Recovery of Cranial Aneurysm Surgery

Acronym: DACA

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Nov 28, 2017
Registry last updated
May 26, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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