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NCT Number: NCT07263165

Dexmedetomidine as an Adjuvant to Bupivacaine for Ultrasound-Guided External Oblique Intercostal Block

Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery.

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Key information

Conditions

Opioid Consumption, Postoperative

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery. A prospectiverandomized clinical trial

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-70 years scheduled for elective upper abdominal cancer surgery (e.g., gastrectomy, hepatectomy, pancreatectomy).
  • American Society of Anesthesiologists (ASA) physical status I-III.
  • Body mass index (BMI) between 18-35 kg/m².

Exclusion criteria

  • Patient refusal.
  • Allergy to local anesthetics or dexmedetomidine.
  • Coagulopathy (INR >1.5, platelet count <100,000/mm³).
  • Infection at the injection site.
  • Severe cardiopulmonary, renal, or hepatic dysfunction.
  • Chronic opioid use (>30 mg morphine equivalents daily for >3 months).
  • Pregnancy or lactation.

Treatment and study plan

Dexmedetomidine

Drug

Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block

Primary outcomes

  1. Total Postoperative Opioid Consumption (mg of morphine equivalents)

    Time frame: 24 hours postoperative.

    To evaluate the effect of adding dexmedetomidine to bupivacaine on total opioid consumption within the first 24 hours after upper abdominal cancer surgery.

Secondary outcomes

  1. Postoperative Pain Intensity Using the Visual Analog Scale (VAS 0-10)

    Time frame: 2, 4, 6, 12, 18, and 24 hours postoperative.

    Pain scores will be assessed at rest and during movement using the Visual Analog Scale (0 = no pain, 10 = worst pain). Higher scores indicate worse pain.

  2. Time to First Request for Rescue Analgesia.

    Time frame: 24 hour postoperative

    Time from block performance until first request for analgesia.

  3. Number of Participants with Adverse Effects

    Time frame: first 2 hours postoperative.

    Incidence of nausea, vomiting, hypotension, and bradycardia.

  4. patient satisfaction score

    Time frame: 1 hour postoperative

    Patient satisfaction regarding pain control (0 = completely dissatisfied, 10 = fully satisfied). Higher scores indicate better satisfaction.

  5. Block-related complications.

    Time frame: intraoperative and 24 postoperative

    Incidence of hematoma, infection, or local anesthetic systemic toxicity (LAST).

Study contacts

Contact information is provided by the study sponsor or research team.

Moaaz M Tohamy

CONTACT

[email protected]

Mohamed i Shaker

CONTACT

[email protected]

01012248619

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Effect of Adding Dexmedetomidine as Adjuvant to Bupivacaine in Ultrasound Guided External Oblique Intercostal Plane Block in Upper Abdominal Cancer Surgery. A Prospective Randomized Clinical Trial

Acronym: Dexmedetomidin

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Dec 4, 2025
Registry last updated
Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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