Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols

Study Objective:

This is a single center, 2-year, blinded prospective randomized study for those diagnosed with rhabdomyolysis age six months-25 years using dexamethasone versus placebo treatment in addition to standard care in up to 50 patients.

Study Design:

Patients will be enrolled with a 2:1 ratio of treatment of dexamethasone for 5 days versus placebo treatment for 5 days in addition to receiving standard care. The treatment period for each subject will be five days treatment with oral treatment once per day with study drug (dexamethasone versus placebo). All patients will also receive standard care. Patients and their parent/ caregiver will have the option to complete surveys before and after treatment in order to assess pain level and treatment improvement. Chart review will be performed on all patients throughout and after the five-day study treatment period. There will be no additional interventions.

Inclusion criteria

• Diagnosis of rhabdomyolysis defined as creatine kinase> 5000 with trauma excluded
• Ability of parents/patients to understand and the willingness to sign a written informed consent document.
• Patients ages 12 and older will sign written assent

Exclusion criteria

• Already taking systemic steroids.
• Inability to comply with study instructions.
• Uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant women.

o A urine pregnancy test will be performed for women of child-bearing potential.

• Below gestational age of 40 weeks
• Allergy to fluconazole, clotrimazole or nystatin.
• Cannot tolerate PO medications