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NCT Number: NCT07088146

Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients

Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.

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Key information

Conditions

Spinal Anesthesia Post Operative Analgesia

Age range

16 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

About this study

To prolong the duration of Sub-Arachnoid block number of drugs which are known as adjuvants can be used. One of the commonly used adjuvant is Dexamethasone a steroid given by intravenous route having anti-emetic and anti-inflammatory effect. This drug also prolongs the duration of Sub-Arachnoid block which can be helpful in case of lengthy surgical procedure and also extends the duration of analgesia in the post operative period.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) class: II and above.
  • Elective Cesarean section under Spinal Anesthesia.

Exclusion criteria

  • Gestational diabetes
  • Body mass index >35 kg/m2
  • Diabetes mellitus
  • Adrenal insufficiency
  • Chronically receiving steroids
  • Allergic to study medications
  • Sensory block level less than T4

Treatment and study plan

Dexamethasone

Drug

Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously

Placebo

Drug

2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia

Primary outcomes

  1. Time for block to regress by two dermatomes in post operative period

    Time frame: This will be the time in minutes from end of C section in post operative period for the block to regress by two dermatomes

Secondary outcomes

  1. Time to rescue analgesia

    Time frame: This will be the time in minutes from the end of Cesarean section in the post operative period to first rescue analgesia.

Study contacts

Contact information is provided by the study sponsor or research team.

Huda Tariq, MBBS

CONTACT

[email protected]

+92-321-8829413

Sponsors and collaborators

Lead sponsor

Rawalpindi Medical College

Other

Registry information

Official study title

Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 28, 2025
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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