NCT Number: NCT02872870
Developmental Language Difficulties: Behavioural and Electrophysiological Studies
This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not. The participants ( dyslexic and dysphasic patients and control adults) will carry out an auditory lexical decision task during which an electroencephalogram (EEG) will be recorded.
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Notify MeKey information
Conditions
Age range
8 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Université catholique de Louvain (IPSY), Louvain-la-Neuve, Belgium
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
(patients):
- Non-verbal intelligence quotient (IQ) less than 85 according to the Wechsler Intelligence Scale for Children (WISC) perceptual index
- Specific oral language disorders diagnosed by the multidisciplinary team (neurologist, psychologist, speech therapist): understanding language deficit, estimated by the test SCOTLAND (Lecocq, 1996) and / or vocabulary test (Dunn Thiébaud).
- Specific written language disorders (dyslexia) diagnosed by a multidisciplinary team according to a test that can objectify the late reading (Alouette) and locate deficits (EVALEC)
- Be affiliated to a social security regimen
- Have signed an informed consent or signed by the parents if the patient is minor
- Aged at least 8 years old
Inclusion criteria
(controls)
- Non-deficit (>85) non-verbal Wechsler Scale (codes and matrices)
- No specific oral language disorders
- No specific written language disorders (dyslexia)
- Be affiliated to a social security regimen
- Have signed an informed consent or signed by the parents if the patient is minor
- Aged at least 8 years old
Exclusion criteria
- Mother tongue other than French
- Non-verbal reasoning abilities below 85 measured by the WISC 4 (for patients only) and Non-verbal capacities of reasoning lower than the normal measured by the non-verbal scale of Wechsler (for controls only)
- Presence of pervasive developmental disorders
- No affiliation to a social security regimen
- Absence of signature of the informed consent
- Subject of less than 8 years
Treatment and study plan
Electroencephalogram
DevicePrimary outcomes
-
Score Alouette reading test
Time frame: at inclusion
In this test, the participant has to read in a loud voice a text, during three minutes. The final score takes into account the speed and the number of errors. For test performance, clinical groups will be compared with its controls.
-
Score EVALEC reading test
Time frame: at inclusion
For test performance, clinical groups will be compared with its controls.
-
Score silence reading test
Time frame: at inclusion
A group of letters will be presented and the participant has to say if this letters compose a known word. For test performance, clinical groups will be compared with its controls.
-
Score of reading comprehension test
Time frame: at inclusion
For test performance, clinical groups will be compared with its controls.
-
Score of Khomsi
Time frame: at inclusion
The objective of this group of different tests is to evaluate comprehension and production of oral language. For test performance, clinical groups will be compared with its controls.
Secondary outcomes
-
Measure of the electroencephalography power spectra
Time frame: at inclusion
For test performance, clinical groups will be compared with its controls.
-
Correlation between electroencephalography power spectra and clinical outcome
Time frame: at inclusion
For test performance, clinical groups will be compared with its controls.
Sponsors and collaborators
Lead sponsor
Lille Catholic University
Other
Collaborators
- University Charles-de-Gaulle
- Université Catholique de Louvain
Registry information
Official study title
Developmental Language Difficulties: Behavioural and Electrophysiological Studies of the Connections Between Spoken and Written Language and Specificity of These Disorders
Acronym: LANGAGE
Important dates
- Study start
- 2012
- Primary completion
- 2015
- Study completion
- 2016
- First posted
- Aug 19, 2016
- Registry last updated
- Aug 19, 2016
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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