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NCT Number: NCT06564779

Development, Standardisation and Standardisation Project for a New Memory Assessment

Episodic memory (EM) is a neuropsychological marker of Alzheimer's disease (AD) (Thomas-Anterion, 2006). Current tests for its assessment do not take into account the identity and emotional aspects of memory (Van der Linden et al., 2018). However, there are models that integrate links with identity, self-awareness and experience. Pause et al. (2013) propose criteria to create ecological tools, including consideration of the emotional valence of memories and the spatio-temporal context of acquisition. In line with these criteria, we have developed a new tool: the NEM (New evaluation of Episodic Memory). Preliminary studies show different response profiles on the NEM among patients (Launay et al., 2023). We now want to evaluate the relevance of this tool in the differential diagnosis of AD.

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Key information

Conditions

Memory Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University hospital

Tours, 37044, France

Location status: Recruiting

Location contact

Alix LAUNAY

CONTACT

[email protected]

0247470458 ext. +33

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 50 years
  • Ability to understand judged sufficient by the assessor;
  • Amnesic MCI profile (Petersen, 2003) during the 1st medical consultation prior to the assessment being prescribed.

Exclusion criteria

  • Severe auditory and/or visual sensory impairment not compatible with neuropsychological assessment;
  • Judged fit to take the test by the assessor;
  • Patient under guardianship, curatorship or family guardianship;
  • Opposition to data processing.

Treatment and study plan

New memory assessment

Other

The intervention is part of the neuropsychological assessment carried out as part of routine care. It consists of carrying out the neuropsychological tests traditionally used to investigate the diagnostic hypothesis of Alzheimer's disease.

Primary outcomes

  1. Score total NEM (new memory assessment)

    Time frame: baseline

    Sum of the episodic elements

Secondary outcomes

  1. NEM sub-scores

    Time frame: baseline

    Sum of the episodic elements by category

  2. Total RL/RI 16 Recall

    Time frame: baseline

    (Van der Linden et al., 2014)

  3. Delayed Mem Logic Recall

    Time frame: baseline

    (MEM IV, Wechsler, 2014)

Study contacts

Contact information is provided by the study sponsor or research team.

Alix LAUNAY

CONTACT

[email protected]

0247470458 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Acronym: NEM

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Aug 21, 2024
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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