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OpenTrials
Completed

NCT Number: NCT04041089

Development of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy

Posterior cortical atrophy (PCA) is manifested by neuro-visual disorders that alter the spatial location of objects, their manipulation and/or recognition. Its etiology is most often neurodegenerative, with a major impact on the autonomy and mood of patients and their families. Few studies have focused on non-medication management of these disorders.

The present study thus has a double objective: the development of a complete tool to work on the recognition, localization and/or manipulation of objects; and the evaluation of the effectiveness of this type of management.

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Key information

Conditions

Posterior Cortical Atrophy

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institut Claude Pompidou - Centre Mémoire de Ressources et de Recherche du CHU de Nice

Nice, Alpes-Maritime, 06100, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >50 years old
  • Male or Female
  • Patients with a diagnosis of PCA according to the criteria of Tang-Wai et al (2004)
  • MMS>15
  • Voluntary, written and informed consent of the patient himself or its legal representative (guardian/curator), with oral consent of the patient in all cases
  • Anti-Alzheimer's and psychotropic treatments stable for one month, if taken by the patient
  • Affiliation to a social security system

Exclusion criteria

  • Uncorrected visual disorders with non-degenerative etiology (AV<0.5)
  • Person under the protection of justice
  • Pregnant women (a pregnancy test will be performed in premenopausal women)

Treatment and study plan

Recognition of objects

Behavioral
  • Name of shapes / colors / images / objects
  • Classification of shapes / colors / images / objects

Location of objects

Behavioral
  • Search for frequent/rarse targets among distractors sharing one or more characteristics with the target
  • Hit/catch a stationary/mobile target as quickly as possible

Manipulation of objects

Behavioral
  • Storage of shapes/objects
  • Use of everyday objects (pen, cutlery, etc.)

Primary outcomes

  1. Effectiveness evaluation

    Time frame: At week 34

    Effectiveness will be evaluated a score based on success rate (from 0 to 10), reaction time and eye-recording .

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Development and Evaluation of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy (PCA)

Acronym: REEDUC-ACP

Important dates

Study start
2019
Primary completion
2021
Study completion
2022
First posted
Aug 1, 2019
Registry last updated
Mar 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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