Development of Specific Diagnostic Tools for Cardiac Insufficiency With Preserved Ejection Fraction

Inclusion criteria

group 1 (ejection fraction ≥ 50%) :

• Age > or = 65,
• heart failure (NT-proBNP ≥ 450 pg/mL during hospitalization or follow-up)
• echocardiography showing an ejection fraction ≥ 50%,
• patients already hospitalized and followed in cardiology consultation,
• patients agreeing to sign informed consent,
• patient affiliated to french health care system.

Inclusion criteria

group 2 (ejection fraction < 50%) :

• Age > or = 65,
• heart failure (NT-proBNP ≥ 450 pg/mL during hospitalization or follow-up)
• echocardiography showing an ejection fraction < 50%,
• patients already hospitalized and followed in cardiology consultation,
• patients agreeing to sign informed consent,
• patient affiliated to french health care system.

Inclusion criteria

group 3 (without heart failure) :

• Age > or = 65,
• patients already hospitalized and followed in cardiology consultation for one of the following pathology : stable coronaropathy without heart failure, arterial hypertension without heart failure, auricular fibrilation without heart failure
• patients agreeing to sign informed consent,
• patient affiliated to french health care system.

Exclusion criteria

for all groups:

• Hemodynamic instability (cardiogenic shock),
• any condition leading to a prognosis of less than 7 days,
• Known hepatocellular insufficiency, or known hepatic cirrhosis
• ASAT / ALAT> 10N excluding cardiac cause
• Any conditions that may put the patient at risk or increase the risk of non-compliance with the protocol or lost to follow-up according to the opinion of the investigator
• Patient under legal protection, under guardianship or under curatorship
• Inability to give the subject informed information
• Pregnant or breastfeeding woman