Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

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Key information

Conditions

Healthy Volunteers

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Academic Unit of Radiology, Univeristy of Sheffield

Sheffield, South Yorkshire, S10 2SJ, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age 18 -70

Exclusion criteria

contraindication to MRI
Resting oxygen saturation <95%
Volunteers requiring bronchodilators less than 4 hourly
additional respiratory diagnoses
pregnancy

Treatment and study plan

polarised 3 helium

Other

1 inhalation (= 1 litre)

Sponsors and collaborators

Lead sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Other

Collaborators

University of Sheffield

Registry information

Important dates

Study start: 2010
Primary completion: 2020
Study completion: 2020
First posted: Nov 5, 2010
Registry last updated: Dec 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed