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NCT Number: NCT05962879

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

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Key information

Conditions

Anxiety Disorders Depressive Disorder Mental Disorders Mood Disorders Psychosocial Functioning Psychotic Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

14 year–19 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location status: Recruiting

Location contact

Nicole R DeTore, PhD

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
  • Endorsed at least one psychotic experience
  • Provided contact information
  • Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
  • Have a parent or legal guardian who is able and willing to participate in a parent session
  • Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
  • Able to communicate in English

Exclusion criteria

  • Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
  • Currently obtaining psychotherapeutic intervention

Treatment and study plan

Resilience Training for Teens

Behavioral

A brief 6-session group-based behavioral intervention for high school aged teenagers at risk of a mental illness.

Primary outcomes

  1. Structured Interview of Psychosis-risk Syndromes (SIPS)

    Time frame: 1 year

    Subclinical psychotic symptoms that represent a risk of transdiagnostic mental illnesses. This semi-structured interview rates psychotic experiences, general symptoms, and functioning. The SIPS interview assesses positive, negative, disorganized, and general symptoms. The range of the Scale of Psychosis-risk Symptoms (SOPS) is 0-6, with a higher score representing more severe symptoms.

Secondary outcomes

  1. Child Behavior Checklist (CBCL)

    Time frame: 1 year

    Mental health symptoms in the teen rated by both the teen and the parent/guardian consisting of 113 items. The CBCL rates multiple domains across functioning and psychiatric diagnoses. It is scored on a 3-point Likert scale, with higher scores representing more severe symptoms.

  2. Global Functioning Social and Role Scales

    Time frame: 1 year

    Social and school/work functioning captured on this scale rated on a 10 point likert scale assessing functional and social functioning separately. Higher ratings represent richer functioning.

Study contacts

Contact information is provided by the study sponsor or research team.

Nicole R DeTore, PhD

CONTACT

[email protected]

617-726-2065

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jul 27, 2023
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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