Development of a Severity Assessment Score for Nasosinus Polyposis (PSI Score)

In practice, during their otolaryngologist (ORL) consultation, patients will have a complete clinical check-up and will be prescribed the necessary complementary examinations if they have not already been performed recently (<6 months). All data will be collected in an anonymous database.

The patient will answer a questionnaire to evaluate the cardinal symptoms of PNS using a visual scale from 0 to 10. He will then have a standard ORL clinical check-up (otoscopy, then rhinoscopy with speculum and nasal endoscopy) in order to make a nasal anatomical assessment (duration 5 minutes).

They will be given a questionnaire on admission to the waiting room to find out the impact of their nasal discomfort on their quality of life (score used routinely and validated in the literature, SNOT-22), as well as a questionnaire concerning their asthma if it exists (score used routinely and validated in the literature, ACT). The importance of the endoscopic involvement will be evaluated using the Lidholt score (see Appendix) and the importance of the radiological involvement directly from the CT or Cone beam computed tomography (=CBCT) results using the Lund-MacKay score. The estimated time to complete these questionnaires and to assess the endoscopic and radiological involvement is an additional 10 minutes. Blood will be drawn (as part of the initial routine workup) to assess complete blood count (for blood hypereosinophilia) and IgE levels (serum and total IgE). We will repeat the assessment routinely performed as part of the follow-up of patients with PNS by questionnaire, interview and physical check-up at 3 months when the patients return for their follow-up visit. No additional exams or questionnaires to the routine workup will be performed for this study.

Inclusion criteria

• >18 years
• Patients included are all adult (>18 years) patients with PNS: Inflammation of the nose and sinuses that is characterised by two or more of the following symptoms (at least one of which must be nasal obstruction or runny nose):
• Nasal obstruction and nasal congestion
• Rhinorrhoea (anterior or posterior)
• Facial pain or pressure
• Decreased or loss of sense of smell
• Sneezing and/or nasal pruritus

These symptoms should be associated with :

• Endoscopic signs of nasal polyps
• Diffuse bilateral naso-sinusal opacities on CT or CBCT

Exclusion criteria

• Decline to participate in the study
• No one who speaks or understands French
• History of skull base surgery for tumours
• History of major head trauma
• History of cerebral-facial radiotherapy or chemotherapy
• History of inflammatory or neurodegenerative neurological pathology
• Systemic disease associated with the presence of sinus polyps (Granulomatosis - with polyangiitis, cystic fibrosis, primary ciliary dyskinesia, immune deficiency)
• Cancer or haematological disease in progress