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Completed

NCT Number: NCT02105077

Development of a Mass-spectometry Based Method for Detecting Xenon Application in Humans

The purpose of this study is to establish a laboratory method to determine from blood samples whether a person has been treated with xenon.

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Key information

Conditions

Anesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf

Düsseldorf, 40225, Germany

About this study

The noble gas xenon is used for general anesthesia in clinical routine. Recent reports indicate that xenon is also used for increasing performance in high-performance sports. The purpose of this study is to establish a method for detecting xenon exposure in humans.

In patients undergoing surgery with xenon anesthesia as part of routine hospital care, small blood samples (3ml) will be taken before anesthesia, during anaesthesia and at 1,2, 4, 8, 16, 24, 32, 40 and 48 hours after anesthesia. These blood samples will be analyzed for traces of xenon.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age of 18 years and older
  • Xenon-based anesthesia as part of routine care

Exclusion criteria

  • Inability to give written informed consent
  • Known pregnancy
  • Hemoglobin concentration of less than 12g/dl

Treatment and study plan

Anesthesia with inhalative application of xenon gas

Drug

Primary outcomes

  1. Detection of xenon in patient blood sample by mass spectrometry

    Time frame: Immediately before induction of anesthesia

  2. Detection of xenon in patient blood sample by mass spectrometry

    Time frame: During xenon anesthesia

  3. Detection of xenon in patient blood sample by mass spectrometry

    Time frame: 4 hours after extubation

  4. Detection of xenon in patient blood sample by mass spectrometry

    Time frame: 8 hours after extubation

  5. Detection of xenon in patient blood sample by mass spectrometry

    Time frame: 24 hours after xenon anesthesia

Sponsors and collaborators

Lead sponsor

Heinrich-Heine University, Duesseldorf

Other

Collaborators

  • German Sport University, Cologne

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Apr 7, 2014
Registry last updated
Mar 31, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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