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NCT Number: NCT06169930

Development and Validation of a Survival Prediction Model for Esophageal Cancer Patients After Esophagectomy

In this retrospective study, we analyzed data from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables.

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Key information

Conditions

Survivorship

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sichuan Cancer Hospital and Research Institute

Chengdu, Sichuan, 610041, China

About this study

In this retrospective study, we analyzed data from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables. Additionally, the receiver operating characteristic curve demonstrated an area under the curve greater than 0.7 at 1, 3, and 5 years in both the verification and training groups. Furthermore, Kaplan-Meier (K-M) curves showed that our model effectively distinguished between high- and low-risk groups (p < 0.01).

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients underwent esophagectomy at our hospital.

Exclusion criteria

  • pathology confirmed a non-squamous cell carcinoma,
  • the tumor was located outside of the thoracic region,
  • R1/R2 resection was performed indicating incomplete tumor removal,
  • evidence of distant tumor metastasis was observed, or
  • they underwent preoperative neoadjuvant therapy

Treatment and study plan

This was an observational study without any intervention

Other

This was an observational study without any intervention

Primary outcomes

  1. Survival

    Time frame: April 2022-April 2024

    Overall survival (OS) was defined as the time from the month and year of surgery until death or the last follow-up in April 2022.

Sponsors and collaborators

Lead sponsor

Yongtao Han

Other

Registry information

Official study title

Development and Validation of A Overall Survival Prediction Model for Esophageal Squamous Cell Carcinoma: A Novel pN Classification

Acronym: OSmodel

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Dec 14, 2023
Registry last updated
Dec 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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