Development and Validation of a Multimodal Artificial Intelligence Model for Early Prediction of Acute Myocardial Infarction

Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index event remains unacceptably high, posing a formidable clinical challenge. Contemporary risk-stratification instruments rely predominantly on a restricted set of conventional clinical variables and therefore fail to capture the full spectrum of individual pathophysiological complexity. To overcome these limitations, the present investigation aims to develop a post-AMI prognostic model that integrates comprehensive multimodal data.

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Key information

Conditions

Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009

Hangzhou, Zhejiang, 310000, China

Location contact

Jun Jiang, MD

CONTACT

[email protected]

+86 15657125311

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years old
Presented with myocardial infarction, including NSTEMI and STEMI
Undergoing successful percutaneous coronary intervention.

Exclusion criteria

1.Poor imaging quality or a data missing rate >30%

Treatment and study plan

Percutaneous coronary intervention

Procedure

Percutaneous coronary intervention

Primary outcomes

Diagnostic performance

Time frame: 6 months

the diagnostic performance (AUC) for predicting the risk of acute myocardial infarction (AMI) within 6 months

Study contacts

Contact information is provided by the study sponsor or research team.

Jun Jiang, MD

CONTACT

[email protected]

+86 15657125311

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2028
First posted: Mar 9, 2026
Registry last updated: Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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