Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06848959

Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models

Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood encephalopathy and a follow-up tracking question and answer system for childhood encephalopathy patients.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Cerebral Palsy Attention Deficit Disorder with Hyperactivity Attention Deficit Hyperactivity Disorder Attention Deficit and Disruptive Behavior Disorders Autism Spectrum Disorder Autism Spectrum Disorders Brain Damage, Chronic Brain Diseases Central Nervous System Diseases Child Development Disorders, Pervasive Intellectual Disability Mental Disorders Mental Retardation Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Tourette's Syndrome

Age range

2 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Nanjing, China

Location status: Recruiting

Location contact

Dong Chen Dr.

CONTACT

[email protected]

+86 134 0587 1656

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1. meet diagnostic criteria for CP ID TD ADHD ASD; 2. gender is not limited;

Exclusion criteria

  • 1. CP ID TD ASD due to chorea hepatomegaly hearing abnormality and pharmacogenetic factors;
  • 2. Children with other major mental illnesses (e.g. schizophrenia) or organic diseases (e.g. congenital heart disease);

Treatment and study plan

No intervention

Other

Pediatric Encephalopathy Science and Prevention Decision Aid Follow-Up Q&A

Primary outcomes

  1. Childhood Autism Rating Scale

    Time frame: 4 mouths

    The total score ranges from 15 to 60, with the higher the score the worse the symptoms are

  2. meridian and acupointological features

    Time frame: 4 mouths

    After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  3. Yale Global Tic Severity Scale

    Time frame: 4 mouths

    It has a score range of 0-100, with higher scores representing more severe symptoms.

  4. Gross Motor Function Assessment Scale (GMFM)-88

    Time frame: 4 mouths

    GMFM-88 scores range from 0-264, with higher scores being better.

  5. Autism Behavior Checklist

    Time frame: 4 mouths

    It has a score range of 0-174, with higher scores representing more severe symptoms.

  6. acupuncture point status

    Time frame: 4 mouths

    After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  7. Tongue texture

    Time frame: 4 mouths

    After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  8. Wechsler intelligence scale (WIS)

    Time frame: 4 mouths

    FIQ = 100: Indicates that the individual has an average level of intelligence. FIQ > 100: Indicates an above average level of intelligence. FIQ < 100: Indicates a below average level of intelligence.

  9. Resting heart rate

    Time frame: 4 mouths

  10. blood pressure (systolic, diastolic) after 10 minutes of rest

    Time frame: 4 mouths

  11. Conners Rating Scales

    Time frame: 4 mouths

    Scores are converted to standardized T-scores for comparison with the mean of the peer group. T-scores above 65 are usually considered clinically significant.

  12. tongue coating, pulse

    Time frame: 4 mouths

    After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  13. respiratory rate

    Time frame: 4 mouths

  14. Body temperature

    Time frame: 4 mouths

Secondary outcomes

  1. Saliva

    Time frame: 4 mouths

    Destruction after use. Metabolomics after sample collection.

  2. blood

    Time frame: 4 mouths

    Destruction after use. Metabolomics after sample collection.

  3. Urine

    Time frame: 4 mouths

    Destruction after use. Metabolomics after sample collection.

  4. Faeces

    Time frame: 4 mouths

    Destruction after use. Metabolomics after sample collection.

Study contacts

Contact information is provided by the study sponsor or research team.

Yun Liu PhD

CONTACT

[email protected]

+86 13023876996

Sponsors and collaborators

Lead sponsor

Yun Liu,PhD

Other

Registry information

Official study title

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 27, 2025
Registry last updated
Feb 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.