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OpenTrials
Completed

NCT Number: NCT05864586

Developing E-liquid Product Standards (Sweet Spot Study)

The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of smoking and older adult smokers.

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Key information

Age range

21 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young adult e-cigarette user or older adult smoker
  • Willing to abstain from all nicotine product use for 12 hours prior to the study visit
  • Read and speak English

Exclusion criteria

  • Currently attempting to quit nicotine products
  • Currently pregnant, planning to become pregnant, or breastfeeding
  • Current or past use of tobacco products other than e-cigarettes or cigarettes
  • Self-reported diagnosis of lung disease
  • Self-reported new or unstable cardiovascular disease

Treatment and study plan

Vaping study EC A

Behavioral

Vaping two puffs using the study EC device

Vaping study EC B

Behavioral

Vaping two puffs using the study EC device

Vaping study EC C

Behavioral

Vaping two puffs using the study EC device

Vaping study EC D

Behavioral

Vaping two puffs using the study EC device

Vaping study EC E

Behavioral

Vaping two puffs using the study EC device

Vaping study EC F

Behavioral

Vaping two puffs using the study EC device

Vaping study EC G

Behavioral

Vaping two puffs using the study EC device

Vaping study EC H

Behavioral

Vaping two puffs using the study EC device

Vaping study EC I

Behavioral

Vaping two puffs using the study EC device

Vaping study EC J

Behavioral

Vaping two puffs using the study EC device

Primary outcomes

  1. Behavioral Intentions for Continued Use

    Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

    Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.

  2. Intensity of Sensory Attributes

    Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

    5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.

  3. Degree of Liking or Disliking of Sensations

    Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

    Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.

Secondary outcomes

  1. Subjective Appeal

    Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

    12-item modified Cigarette Evaluation Questionnaire (mCEQ) completed following e-cigarette self-administration to assess subjective responses to the e-cigarettes. The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Scores for each subscale are calculated as the mean of the individual item responses or the single item. Higher scores indicate greater intensity on that scale.

Sponsors and collaborators

Lead sponsor

Ohio State University Comprehensive Cancer Center

Other

Registry information

Official study title

Nicotine Concentration and Forms: Differential Appeal to Smokers Versus Non-Smokers

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
May 18, 2023
Registry last updated
Apr 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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